The Developing Nervous System, Acetaminophen Effects, and More Are in the Spotlight in the June 2025 Issue of ToxSci | Newswise
Newswise — The June 2025 issue of Toxicological Sciences includes an In-Depth Review that shares a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing, while a Research Brief explores the safety of acetaminophen exposure during gestation. Also, a #ToxSpotlight article reviews a workflow for human health hazard evaluation using transcriptomic data and key characteristics-based gene sets.
Other papers in the June 2025 issue (sorted by topic category) are:
Biotransformation, Toxicokinetics, and Pharmacokinetics
“An Open-Source Interactive Physiologically Based Pharmacokinetic Model of Tylosin in Broiler Chickens and Laying Hens”
Clinical and Translational Toxicology
“Gallic Acid Relieved Bortezomib-Induced Peripheral Neurotoxicity by Restoring Schwann Cell Lysosomal Activity”
Developmental and Reproductive Toxicology
“A Mixture Parameterized Biologically Based Dosimetry Model to Predict Body Burdens of Polycyclic Aromatic Hydrocarbons in Developmental Zebrafish Toxicity Assays” (open access)
“Transgenerational Effects of Perinatal Cannabis Exposure on Female Reproductive Parameters in Mice”
Emerging Technologies, Methods, and Models
“An Analytical Screening Platform to Differentiate Acute and Prolonged Exposures of Per- and Polyfluoroalkyl Substances on Invasive Cellular Phenotypes”
Molecular, Biochemical, And Systems Toxicology
“Dose–Response Modeling of Effects in Mice After Exposure to a Polyfluoroalkyl Substance (Nafion Byproduct 2)”
Organ Specific Toxicology
“Establishing a Context of Use for Three-Dimensional Cardiac Tissue Derived from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using Inotropes” (open access)
About Toxicological Sciences
The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology. The journal’s primary focus is on original research articles, but it also provides expert insight via contemporary, in-depth, and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field.
About the Society of Toxicology (SOT)
Founded in 1961, SOT is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of scientists who practice toxicology around the world. The Society’s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology.
