Non-Coding RNAs in Adipose-Derived Stem Cell Exosomes: Mechanisms, Therapeutic Potential, and Challenges in Wound Healing | Newswise
Newswise — The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options. Adipose-derived stem cell exosomes (ADSC-Exos) are promising for their capabilities to enhance angiogenesis, mitigate oxidative stress, modulate inflammatory pathways, support skin cell regeneration, and promote epithelialization. These exosomes deliver non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, which facilitate collagen remodeling, reduce scar formation, and expedite wound healing. This study reviews the mechanisms, therapeutic roles, and challenges of non-coding RNA-loaded ADSC-Exos in wound healing and identifies critical directions for future research. It aims to provide insights for researchers into the potential mechanisms and clinical applications of ADSC-Exos non-coding RNAs in wound healing.
Key Words: Adipose-derived stem cell exosomes; Wound healing; MicroRNAs; Long non-coding RNAs; Circular RNAs
Core Tip: Wound healing progresses through four interrelated phases: Haemostasis, inflammation, proliferation, and remodelling. These phases are highly coordinated and synergistic, facilitating tissue repair. In recent years, it has been found that non-coding RNAs derived from adipose-derived stem cell exosomes promote wound healing via working on various stages of wound healing. This review explores the mechanisms, functions, and challenges of non-coding RNAs derived from adipose-derived stem cell exosomes in wound healing, providing a theoretical basis and suggested directions for further basic research and clinical applications of these exosomes.
