Mesenchymal Stem Cell-Derived Extracellular Vesicles: Pioneering the Next Generation of Biomedical Applications | Newswise
Newswise — Mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) represent the next generation of biomedical applications, offering advantages over MSCs such as higher stability and lower immunogenicity. As cell-free nanoparticles MSC-EVs have demonstrated both efficacy and safety in the treatment of a range of diseases. This article discussed the applications of MSC-EVs in hair regeneration, immunomodulation, and the treatment of acute kidney injury. MSC-EVs promote hair regeneration by enhancing dermal papilla cell proliferation and migration. They also modulate immune responses and mitigate inflammation through immune-related signaling pathways. Additionally, MSC-EVs contribute to improved renal function by modulating multiple signaling pathways. Despite these promising applications challenges remain in the clinical translation of MSC-EVs. Overcoming these challenges requires extensive research to fully optimize the therapeutic potential of MSC-EVs and advance their translation into clinical practice.
Key Words: Mesenchymal stem cells; Extracellular vesicles; Nanoparticles; Hair regeneration; Immunomodulation; Acute kidney injury
Core Tip: Mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) are cell-free nanoparticles that offer several advantages over MSCs, including greater stability and lower immunogenicity. These vesicles have shown significant potential in the treatment of various diseases. This article explored the applications of MSC-EVs in hair regeneration, immunomodulation, and the treatment of acute kidney injury. It also highlighted the challenges associated with MSC-EV-based therapies, underscoring the need for continued research and innovation to address these obstacles and advance MSC-EV development and clinical translation.
